Description:

RADIONUCLIDIC AND NON-RADIONUCLIDIC MOLECULAR IMAGING AGENTS FOR THE ESTROGEN RECEPTOR BASED ON 11-BETA SUBSTITUTED STEROIDAL ANTI-ESTROGENS

INV-13041

INVENTORS:  Robert N. Hanson, Kinh-Luan (Lenny) Dao

Link to PDF

Description

Currently, only few agents capable of noninvasive imaging for breast cancer are available.  F-18 16 alpha-fluoro-estradiol (FES) is among the most common agents used in this regards.  However, such agents are highly prone to in-vivo metabolism, are less stable, and are associated with higher liver update, and lower renal clearance.  This approach discloses the development and use of a novel imaging technique comprising the use of novel agents to target estrogen receptors for visualization of tissues associated with variety of modalities.

 

Value Proposition

The technique:

•Utilizes novel steroidal derivatives as imaging agents

•Allows for an easier separation of unlabelled precursors

•Is based on high affinity anti-estrogen structure as compared to current estrogenic materials

•Allows for use of more stable and high affinity agents as compared to conventional techniques

•Comprising the use of 11-beta substituted steroidal anti-estrogens as probes for ER selectivity and affinity

•Allows for an easier detection of lesions in breast, ovaries, and uterus as compared to conventional techniques

•Further allows for a reduced metabolism of agents as compared to conventional techniques

•Is modular in nature, comprising independent preparation of various components followed by incorporation using simple chemistries and physic-chemical diversities

•Would be commercially useful for variety of applications such as PET, SPECT, Fluorescence, MRI and Raman especially for imaging at a cell, tissue, and a whole animal scale

 

Intellectual Property status

Provisional Application 61/735,184

License status

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Robert Hanson
Kinh-Luan (Lenny) Dao
Keywords:
Cancer
Chemistry
Diagnostics
Health
Medical Imaging
Medical/Health
Science/Research