Description:

COMPOUNDS AND METHODS FOR TARGETED IMMUNE SYSTEM DELIVERY

INV-1151

INVENTORS: Juan Sebastian Pappalardo, Micaela Toniutti, Stefano Salmaso, Tatyana S. Levchenko, Vladimir P. Torchillin

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Description

Currently, few immune system targeting delivery mechanisms are available. Most of these mechanisms use complex chemistry, making it difficult to identify exact binding percentages. Furthermore, many such procedures even use bromination and de-bromination techniques, making the procedure more expensive, multi-stepped, and with reduced yield.  This approach discloses the development and use of novel compounds to effectively target dendritic cells.

Value Proposition

The approach:

•Is highly cost effective and is capable of operating at a much larger scale

•Allows for a higher percentage of specific binding as compared to prior-art procedures

•Allows for an improved delivery of compounds as compared to conventional approaches

•Triggers a desired response in dendritic cells, leading to their timely activation

•Allows for an effective regulation of the immune system as compared to conventional approaches

•Uses liposomes that are stable and slightly negatively charged as compared to conventional approaches

•Would be commercially useful for treating various disorders such as HIV, HBV, HCV, herpes viruses, autoimmune disorders, transplant rejection, and cancer

 

Intellectual Property status

Provisional Application 61/709,616

License status

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Vladimir Torchilin
Tatiana Levchenko
Juan Pappalardo
Stefano Salmaso
Micaela Toniutti
Keywords:
Cancer
Chemistry
Drug Delivery
Genome
Health
Healthcare Innovation
Medical
Nanomedicine
Research Tool