Description:

MULTI-COMPARTMENTAL MACROPHAGE DELIVERY

INV-1028

INVENTORS:  Mansoor M. Amiji, Mayur Kalariya, Shardool Jain, Husain Attarwala

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Description

Macrophages play an important role in regulating biological processes, mainly related to inflammatory and infectious diseases.  These macrophages get converted from a rested state into an active state to tackle such disorders, wherein the activation is mediated by key activation sources such as cytokines and certain microbial products (such as lipopolysaccharides).  This novel approach enables the development and use of compositions for delivery of imaging or therapeutic agents to macrophages.

 

Value Proposition

The composition:

•Is a multi-compartmental nanoparticulate delivery system (nanoparticles encapsulated within a microsphere) for safe and efficient delivery of agents

•Has an ability to overcome various intra and inter tissue barriers and to effectively deliver the agents at desired biological sites

•Has an ability to effectively compartmentalize various system components/delivery agents to improve the overall structural stability and to avoid any potential incompatibility issues

•Is capable of simultaneously delivering incompatible agents (such as hydrophilic and lipophilic agents)

•Allows for temporal control over the release of agents

•Would be effectively used for various commercial applications such as disease diagnosis, imaging, gene therapy, gene silencing, cancer treatments, and vaccination

 

Intellectual Property status

Pending Utility Application 13/636,900

Pending European National Application 11760255.7

Pending Japan National Application

License status 

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Mansoor Amiji
Husain Attarwala
Shardool Jain
Mayur Kalariya
Keywords:
Biotech
Breast Cancer
Cancer
Chemotherapy
Drug Delivery
Drugs
Health
Medical
Nanomedicine