Description:

MULTIMODAL DIAGNOSTIC TECHNOLOGY FOR EARLY STAGE CANCER LESIONS

INV-1030

INVENTORS:  Mansoor M Amiji, Srinivas Ganta, Pei-Chin Tsai

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Description

Millions of new cancer cases are diagnosed every year.  Current cancer diagnostic techniques majorly detect tissue transformation especially in advanced stages of the disease, wherein the cancer patients already start developing clinical symptoms.  This novel multimodal composition allows an early stage cancer diagnosis (even at a precancerous stage), leading to better prognosis and total cure of the disease.

 

Value Proposition

The composition:

•Comprises a plurality of metallic nanoparticles (2-30 nm) suitable for functionalization with target specific binding agents (such as antibodies, fab fragments, or binding fragments thereof), wherein such nanoparticles are attached to a polymeric carrier (500 nm to 10 microns) having encapsulated imaging agents for generating detection signals

•Allows for further coating of polymeric carriers with a hydrophilic gelling material, which may be biodegradable or biocompatible in nature

•Effectively detects a cell/tissue morphology as compared to conventional compositions

•Enables an early diagnosis of superficial tumor lesions as compared to conventional compositions

•Would be commercially useful for diagnosis of various cancer types such as oral, esophageal, stomach, and colon

 

Intellectual Property status

Pending Utility Application 13/636,877

Pending European National Application 11760209.4

Pending Japan National Application

License status 

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Mansoor Amiji
Srinivas Ganta
Pei-Chin Tsai
Keywords:
Biotech
Cancer
Dental Indication
Detection
Diagnostics
Gastrointestinal Disease
Medical/Health
Nanomedicine