Description:

DRAWING COLLAGEN FIBERS FROM A SOLUTION OF MONOMERS

INV-13057

INVENTORS:  Jeffrey Paten, Jeffrey William Ruberti

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Description

Conventionally, many procedures have been developed and used for assembly of polymeric fibers such as collagen fibrils; however, none of the existing procedures are customized.  Moreover, the strain directed assembly of collagen fibrils has never been disclosed earlier.  Some of the other limitations associated with existing procedures/techniques are fabrication of unorganized fibrils, non-reproducibility, assembly of small sized fibrils, and reduced efficacy.  This approach discloses a novel procedure for fabrication of collagen fibers from a solution of monomers.

 

Value Proposition

The procedure:

•Is highly repeatable

•Effectively allows for a strain directed assembly of collagen fibrils

•Allows for an assembly of highly organized and aligned collagen fibrils

•Enables the use of a solution/air interface to generate the required strain

•Is highly customized, enabling change of collagen concentration ranges, magnitude/distribution of strain and the rehydration environment

•Allows for a fiber drawing rate of 1micron/sec to 1cm/sec

•Allows for the concentration of accumulated monomers in the preferred range of 2.4-100 mg/ml

•Enables an adjustment of key process parameters such as temperature, ionic strength, pH and buffers

•Would be commercially useful for various applications such as:

o Fabrication of connective tissues

o Organized scaffolding for regenerative medicine

o Tissue repair

o Alignment guide for other molecules such as carbon nanotubes

 

Intellectual Property status

Provisional Application 61/760,396

License status

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Jeffrey Paten
Jeffrey Ruberti
Keywords: