Description:

METHODS OF GENERATION OF BROADLY NEUTRALIZING ANTI-PATHOGEN ANTIBODIES

INV-13070

INVENTORS:  Michail V. Sitkovsky, Robert Koehler Abbott, Stephen Matthew Hatfield

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Description

In prior art, an immunization/vaccination protocol to combat a deadly disease like AIDS is non-existent.  Further, most of the biological processes involved in generating protective immunity are unknown.  As a result, there has been an evident failure to develop effective vaccines against such infectious diseases and related pathogens.  This invention discloses a novel procedure for development and use of a vaccine adjunct/immunization strategy for an enhanced vaccine response, effective against infectious diseases such as AIDS and Malaria, overcoming existing unmet needs and other prior art limitations.

 

Value Proposition

The procedure:

•Leads to an efficient generation of broadly neutralizing, high affinity, and high-titer antibodies

•Involves the use of a counterintuitive protocol for immunization where immunosuppressive agents (such as A2aR and A2bR agonists (or other GPCR agonists)) are used

•Targets a hypoxic adenosinergic system to generate an enhanced immune response

•Allows for a faster and larger quantity antibody production as compared to traditional approaches

•Is associated with an improved/enhanced antibody response as compared to conventional immunization approaches

•Further involves an accelerated class switching and increased B-cell activation (with induced hypermutation of variable region immune globulin gene) in vitro

•Would be commercially useful for applications such as potential vaccination/immunization against all infectious diseases, and for improvement in existing vaccines/vaccination techniques

 

Intellectual Property status

Provisional Application No. 61/803,066

License status

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Michail Sitkovsky
Robert Abbott
Stephen Hatfield
Keywords:
Biology
Infectious Disease (including AIDS)
Method
Treatment
Vaccine