Description:

NOVEL CANNABINERGIC NITRATE ESTERS AND RELATED ANALOGS

INV-1247

INVENTORS:  Alexandros Makriyannis, Venkata Kiran Vemuri

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Description

In prior art, various attempts have been made to explore and understand the medicinal effects of marijuana unrelated to its psychoactive properties.  As a result, various cannabinoidal compounds have been identified and experimented till date.  However, identification of cannabinoidal compounds with nitrate ester groups have never been reported or studied.  This approach discloses development and use of such novel compounds for various therapeutic/research applications.

 

Value Proposition

The cannabinergic nitrate esters:

•Exhibit a dual functional behavior

•Are good nitric oxide donors

•Have improved physiochemical properties

•Are capable of covalently binding to receptors in a unique manner

•Have a predictable onset and duration of action as compared to conventional compounds

•Possess exceptional and distinct in-vivo and in-vitro pharmacological properties

•Are capable of acting as agonists, partial agonists, neutral antagonists or inverse agonists for various receptors

 

Intellectual Property status

Provisional Application 61/769,410

License status

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Alexandros Makriyannis
Venkata Kiran Vemuri
Keywords:
Chemistry
Drug Discovery & Development
Drugs
Therapeutic