Description:

PRECISION-GUIDED NANOPARTICLE SYSTEMS FOR DRUG DELIVERY

INV-0726

INVENTORS:  Robert N. Hanson, Mansoor Amiji, Volkmar Weissig

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Description

Most commonly, the targeted nanoparticles are prepared using a linear process involving nanoparticle synthesis, surface functionalization, linker attachment and terminal ligation of a targeting molecule.  Introduction of multiple functional units onto nanoparticles surface using such a methodology is an extremely difficult task.  This approach involves preparation of novel nanoparticle based targeted delivery systems, overcoming the prior art limitations.

 

Value Proposition

The delivery system:

•Is made up of multifunctionalized/multivalent nanoparticles, capable of attaching to multiple targeting and effector agents

•Is prepared using a convergent approach, wherein the modified nanoparticles and modified targeting moieties are at first prepared separately and are then ligated accordingly using a series of chemical/biorthogonal reactions (ligation of half-linkers)

•Overcomes the need for (hetero) bifunctional linkers as observed with conventional techniques

•Is useful for précised/controlled targeted (to tissues and/or intracellular organelles) delivery of therapeutic and imaging agents

•Is commercially useful for the treatment and/or diagnosis of neoplastic (such as breast cancer), infectious, and chronic diseases

 

Intellectual Property status

Pending Utility Application 12/256,297

License status 

Available for license

Patent Information:
Category(s):
Drug Delivery
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Robert Hanson
Mansoor Amiji
Volkmar Weissig
Keywords:
Drug Delivery
Nanomedicine