Description:

MULTIFUNCTIONAL SELF-ASSEMBLING POLYMERIC NANOSYSTEMS

INV-0908

INVENTORS: Mansoor M. Amiji, Arun K. Iyer

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Description

Most prior-art approaches utilize cationic lipids and polymers for delivery of negatively charged nucleic acid moieties by forming electrostatic complexes.  Such approaches are not efficient in gene therapy or RNA interference due to lack of their intracellular release and stability. Moreover, such moieties (cationic lipids and polymers) are extremely toxic to cell and tissues. This novel multifunctional self-assembled polymeric nano-system enables physical encapsulation of nucleic acid constructs in a neural or anionic matrix for many therapeutic and/or imaging applications.

 

Value Proposition

The nano-system assembly:

•Is non-toxic and biocompatible

•Allows for a sustained and efficient delivery of nucleic acids to diseased tissues and cells as compared to conventional approaches

•Enables an effective in-vivo and in-vitro delivery

•Enables screening of large pool of potential drug candidates to identify effective therapeutic moieties

•Would be commercially useful for treatment/diagnosis of various indications such as cancer, coronary restenosis, diabetes, neurodegenerative disease, inflammatory disease, and infectious disease

 

Intellectual Property status

Pending European National Application 09819950.8

Pending Australia National Application 2009302217

Pending Canada National Application 2,740,125

Pending Japan National Application 2011-531209

Pending United States National Application 13/123,428

License status 

Available for license

Patent Information:
Category(s):
Nanotechnology
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Mansoor Amiji
Arun Iyer
Keywords:
Nanotechnology