Description:

UPREGULATING UNIQUE SECRETED BACTERIAL MOLECULES FOR RAPID SCREENING

INV-14008

INVENTORS:  Edgar D. Goluch, Hunter J. Sismaet, Thaddaeus A. Webster

Description       

Pseudomonas aeroginosa is one of the widespread bacterial species affecting people with compromised immune systems.  Currently available bacterial detection techniques use blood from horseshoe crabs.  Such techniques are time consuming and require the physical manipulation of cells.  This invention discloses a novel bacterial detection technique involving use of up-regulated secretary molecules, enabling rapid screening.

Value Proposition

The procedure:

•Uses highly efficient, nanofluidic electrode assemblies for detection

•Is less time consuming as compared to conventional techniques

•Further provides a coupling facility in case of non-electroactive molecules

•Completely avoids nucleic acid amplification requirement as observed with conventional techniques

•Avoids physical manipulation of bacterial cells as observed conventionally

•Allows for monitoring of bacteria through its production of pyocyanin or other redox active molecules secreted by        bacteria

•Would be commercially useful for detection of bacterial species responsible for sepsis such as E. Coli and P. Aeroginosa

 

Intellectual Property status

Provisional Application 61/871,373

 

License status

Available for license

 

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Edgar Goluch
Hunter Sismaet
Thaddaeus Webster
Keywords:
Biology
Diagnostic Software
Microbiology