Description:

METHODS AND COMPOSITIONS FOR EX-VIVO GENERATION OF DEVELOPMENTALLY COMPETENT EGGS FROM GERMLINE CELLS USING AUTOLOGOUS CELL SYSTEMS

INV-14038

INVENTORS:  Jonathan Lee Tilly, Dori Cousins Woods

 

Description       

In USA, about 7,000,000 couples suffer from infertility; however, only less than 2% of such infertile couples actually undergo assisted reproduction.  Many factors contribute to such a lower percentage of treatments. Besides the high treatment cost, the other most common factor is the lack of suitable IVF candidates capable of generating competent eggs (oocytes).  Advanced maternal age and premature ovarian failure are mainly responsible for this issue.  This invention discloses a novel method and a composition for ex-vivo generation of developmentally competent eggs, and potentially addressing existing limitations and/or unmet needs.

 

Value Proposition

The method/composition:

•Is highly cost effective

•Is performed ex-vivo (outside the body)

•Allows for a significant improvement in physical and psychological well-being for women undergoing fertility        procedures

•Provides a novel means for treating infertility in women that are incompatible with current assisted reproduction        techniques

•Allows for effective facilitation, restoration, or promotion of new oocyte and follicle formation

•Utilizes a specific combination of tissues and cells from the same individual to generate functional eggs

•Opens up fertility options for a larger segment of population as compared to conventional techniques

•Is further useful for improving the production of animal species

•Is useful for incorporating desired genetic manipulations in eggs prior to fertilization and embryogenesis, leading to improvements in fertilization and embryo development

 

Intellectual Property status

Provisional Application 61/887,569

License status

Available for license

 

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Jonathan Tilly
Doris Woods
Keywords:
Biotech
Materials
Medical Device
Method