Description:

SYNTHESIS AND DESIGN OF SILVER NANOPARTICLES EMBEDDED mPEG-PDLLA POLYMERSOME NANOCARRIERS

INV-14063

INVENTORS: Benjamin Geilich, Thomas Webster

Description       

Till date, bacterial genetic resistance to antibiotics has been a major threat to global healthcare management. Infections caused by such bacteria are extremely difficult to treat. Researchers have tried various mechanisms and technologies to overcome this issue; however, none of the existing mechanisms are really effective as they are associated with one or more limitations such as multiple dosage requirements, ineffective treatment (infection relapse) and reduced antibiotic shelf life. This invention relates to the development and use of novel, silver nanoparticles embedded polymersome nanocarriers to effectively target such antibiotic resistant bacteria.

 

Value Proposition

The nanocarrier:

•Allows for combination of multiple drugs into one system, enabling effective treatment of complex infections

•Provides a long lasting and time release treatment as compared to conventional systems

•Helps in effectively overcoming bacterial genetic resistance to antibiotics

•Allows for release of antibiotics over several weeks, reducing the number of dosages as well as infection relapse        potential

•Enables a reduced antibiotic degradation as compared to conventional systems

•Allows for an ideal particle size, enabling desirable retention time within the biological system

•Would be commercially useful for the following applications:

oTreatment of life-threatening infections especially related to antibiotic resistant bacteria

oReduction in spread of bacterial generic resistance against antibiotics

oElimination of persistent infections

oMedical device/implant coatings for reducing medical device-related infections

 

Intellectual Property status

Provisional Application 61/951,638

License status

Available for license

 

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Thomas Webster
Benjamin Geilich
Keywords:
Antimicrobial
Health
Medical Device
Nanomedicine
Nanotechnology