Description:

C18R7RGDS SELF-ASSEMBLED AMPHIPHILIC PEPTIDE NANOPARTICLES (APNPS) AS A NOVEL HYDROPHOBIC DRUG CARRIER IN AQUEOUS SOLUTION

INV-15003

INVENTORS: Run Chang; Linlin Sun; Thomas Jay Webster

 

Description       

In prior-art, the use of drug carriers for improving the drug delivery is well known. However, only few carriers are capable of delivering hydrophobic drugs effectively. Moreover, the drug encapsulation procedures used by such carriers, especially for hydrophobic drugs, are highly cumbersome. In addition, some of the commonly used drug delivery carriers such as liposomes are highly toxic in nature, capable of inducing kidney damage (s). This invention relates to a novel and efficient hydrophobic drug carrier comprising self-assembled amphiphilic peptide nanoparticles, capable of overcoming prior-art limitations and/or addressing unmet needs.

 

Value Proposition

The drug carrier:

•Is a potential chemotherapeutic candidate, highly selective for osteosarcoma cells

•Uses a simplified process for encapsulating hydrophobic drugs

•Comprises nano-scale biomaterials for various nano-medicine applications

•Enables an efficient cell penetration, especially for cancerous cells

•Allows encapsulation of external molecules and delivery inside cells/tissues

•Has an effective/enhanced drug loading capability as compared to conventional carriers

•Allows dissolution of hydrophobic drugs to form a homogeneous solution in water

•Allows for an improved drug delivery, especially for indications such as cancer, diabetes, osteoporosis, and tissue regeneration

 

Intellectual Property status

Provisional Application 62/021,857

 

License status

Available for license

 

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Thomas Webster
Run Chang
Linlin Sun
Keywords:
Biology
Drug Delivery
Drug Discovery & Development
Nanomedicine
Therapeutic