Description:

MECHANICALLY DRIVEN, ALLOSTERIC REGULATION OF EXTRACELLULAR MOLECULES

INV-15050

INVENTORS: Jeffrey A. Paten, Jeffrey W. Ruberti

 

Description       

Extracellular matrix (ECM) tissues generally heal slowly due to low cell populations, low vascularity and age-related lowered metabolic activity. Any ECM injury leads to the formation of scar tissue (having reduced molecular organization), diminished mechanical properties, and inferior mobility. The repair/treatment of major damages generally involves use of surgical techniques; however, the actual repair is still reliant on cellular production. Moreover, in many injuries, cells vacate the injury area or undergo apoptosis, leading to an impaired repair. This invention relates to a novel procedure/technique and the related system for allosteric regulation of extracellular molecules, leading to an enhanced/accelerated repair of the damaged biological tissues as compared to conventional procedures/techniques.

 

Value Proposition

The system/procedure:

•Significantly improves the extent of damaged tissue restoration

•Enables creation of a biological junction to restore a nominal strain on ECM across the repair

•Accelerate the recovery of an injured tendon (6-7 times the natural rate of repair, which is generally 4-5 months)

•Allows for exogenous repair of damaged tissues in lieu of biological procedures to either up-regulate or down-regulate specific cellular products

•Directly supply the appropriate biological materials (cocktail of biological molecules) that comprise healthy tendon

•Effectively regulates the chemical and molecular extracellular environment present during the tissue repair, alleviating the burden/reliance placed on biological response

•Would be commercially useful for the following applications:

•Scar prevention

•Scaffold creation

•Accelerated healing

•Replacement of tissue creation

•Disease treatment (destabilization of cancerous tumor)

•Creating, assembling, growing, repairing, or degrading any tissue containing extracellular molecules

 

Intellectual Property status

Provisional Application 62/092,162

 

License status

Available for license

 

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Jeffrey Paten
Jeffrey Ruberti
Keywords:
Cancer
Health
Medical Device
Medical/Health
Nanomedicine
Tissue Engineering