Description:

A new class of conductive, polymer-based biomaterials for use in tissue engineering, and other applications

 

Background:

Conductive polymer-based biomaterials play a crucial role in tissue engineering as they have the ability to regulate cellular behavior.  However, they also pose several challenges, including poor polymer-cell interaction (due to the absence of cell interaction sites), hydrophobicity, poor solubility and processability, as well as uncontrollable mechanical properties.  Additionally, keeping conductive polymers in vivo for long periods of time may trigger inflammatory responses and the need for follow-up surgical procedures.  Therefore, there is an unmet need for the development of biocompatible, biodegradable, and conductive biomaterials with tunable conductivity and physical properties.

 

Description:

This technology involves a new class of conductive polymer-based biomaterials, developed through conductive bio-ionic liquid (BIL) functionalization of biopolymers.  Functionalization of biopolymers with bio-ionic liquid can provide conductivity to the polymer networks while preserving the biomedical and physical characteristics of the biopolymer, making them unique candidates for various tissue engineering applications.

 

Novel features:

o Biocompatibility and biodegradability with tunable mechanical and electric properties

o The process can be applied to a wide range of natural and synthetic polymers

o Safe, injectable hydrogel

o Overcomes issues of solubility, biodegradability, and cytotoxicity

o Can be used in a variety of applications, including: tissue engineering (cardiac tissue regeneration, muscle tissue regeneration, brain tissue engineering), drug delivery, biosensors, flexible electronics and bioactuators.

 

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Nasim Annabi
Iman Noshadi
Keywords: