Description:
 
Background
Different types of biological tissue have specific functions that are enabled by their unique structure. Tissue functions include transporting nutrients into a tissue, or byproducts out of a tissue, metabolic function, load-bearing, actuation, the transmission of nervous system stimuli. Some of the tissue’s structural features are at small length scales, such as the scale of individual cells and extracellular matrix. 
The proposed technology is a folded architecture for creating multi-material, multi-functional microfluidic devices suitable for tissue engineering.
 
Technology Overview
In this invention, different functions are incorporated into a microfluidic device or engineered tissue by the interlocked folding of two or more planar sheets of different materials. The materials of the constituent layers can be cut, patterned and imbued with absorbing materials, coatings, or other functional inclusions.
The layers are biodegradable for implantable tissues and stable for external use (e.g. drug screening). The layers are coated with adhesive to ensure that the co-folded layers remain in place after the folding is complete. 
This invention is similar to the structure of liver tissue through the interlock folding of two materials.
 
Benefits
- No alignment tooling is required to manufacture complex, 3D systems
- A single process integrates multiple materials
- Multiple device functions can be incorporated 
 
Applications
- Tissue engineering for drug screening 
- Tissue engineering for implants 
- Microfluidic test devices for point of care diagnostic
 
Opportunity
- License
- Partnering
- Research Collaboration
Patent Information:
Category(s):
Bio-Engineering
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Carol Livermore
Tian Liu
Robert Lang
Xin Xie
Roger Alperin
Keywords: