Description:
 
Background
Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures can lead to scar tissue formation, hinder nerve regeneration, and prevent functional recovery. 
Fibrin-based adhesives have been widely used for nerve reconstruction, but their low adhesiveness and mechanical strength, as well as their inability to promote nerve regeneration often limits their utility. 
Current formulations of fibrin-based glues are not designed to actively promote regeneration, nor are they mechanically robust enough to significantly reduce the need for sutures in the highly dynamic environment of the peripheral nervous system (PNS).
 
Technology Overview
In this invention, Northeastern researchers use photocrosslinkable gelatin/elastin composites that support the growth of neurites and provide increased adhesive strength to tissues, reducing the need for suturing. 
 
Benefits
- Stronger tissue adhesion 
- Rapidly/easily cross‑linked
- Cell-delivery vehicle
- Elastic
- Biocompatible and biodegradable 
 
Applications
- Uses in the clinic as an alternative to fibrin-based glues for nerve repair
- To fill the lumen of nerve conduits (cell-laden or not)
- Can be used to promote regeneration and repair damaged nerve tissue 
 
Opportunity
- License
- Partnering
- Research collaboration
Patent Information:
Category(s):
Therapeutic
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Jonathan Soucy
Ehsan Shirzaei Sani
Abigail Koppes
Ryan Koppes
Nasim Annabi
Keywords: