Description:
 
Background
Modern cellular imaging tools have revolutionized experimental capabilities for cellular and physiological investigations.
 
Technology Overview
This invention relates to the development of an FMRI-based nanosensor that can continuously and reversibly respond to a physiological release of acetylcholine in the brain of live animal models. 
The nanosensor is based on pairing a pH-sensitive MRI probe with enzymatic recognition of acetylcholine in a nano-scale scaffold that will detect the local pH changes created by the hydrolysis of acetylcholine. 
 
Benefits
- Can be used to monitor spatiotemporal distribution
- Can monitor the activity of acetylcholine in the brain
- It can generate a data set which enables measurement of neural connectivity differences between healthy and diseased tissues
 
Applications
- Imaging probes for MRI – brain, whole body
- Disease imaging
- Small animal imaging 
 
Opportunity
- License
- Partnering
- Research Collaboration
Patent Information:
Category(s):
Biotechnology
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Heather Clark
Yi Luo
Keywords: