Description:
 
Background
This technology is used for quantitative magnetic resonance imaging (MRI). By utilizing an ultra-short time-to-echo (UTE) pulse sequence, iron-oxide nanoparticles (IONP), and optimized acquisition parameters to obtain the purely T1-weighted quantitative signal. While any IONP can be used, this method uses ferumoxytol because of its clinical relevance.
 
Technology Overview
In this method, the combination of iron-oxide nanoparticles and ultra-short time-to-echo imaging is an approach termed as Quantitative Ultra-short Time-to-Echo Contrast-Enhanced (QUTE-CE) MRI. 
The ability to achieve robust, reproducible results is primarily physical, contingent on multi-parametric optimization of TE, TR, and flip-angle. By choosing optimized image acquisition parameters to obtain quantitative signal intensity results, and thus forgo the need for a baseline measurement for each scan.
This method relies on a one-time calibration of imaging protocols using phantoms for Bruker machines, for a given MRI scanner and coil-type. 
It can achieve highly detailed vascular images. However, the quantitative signal allows for a simple partial volume (blood and tissue) measurement for the blood volume fraction (BVF). 
 
Benefits
- Implementable for immediate clinical use by utilizing existing MRI scanners and ferumoxytol
- Produces clear vascular images
- Significant improvement in the field for measuring concentration
- Can be used for diagnostic purposes throughout the whole brain or organ of interest
 
Applications
- Brain biomarker
- Diagnostics
- Magnetic resonance angiography
 
Opportunity
- License
- Partnering
- Research Collaboration
Patent Information:
Category(s):
Imaging
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Srinivas Sridhar
Codi Gharagouzloo
Keywords: