Description:

DRAWING COLLAGEN FIBERS FROM A SOLUTION OF MONOMERS

INV-13057

INVENTORS:  Jeffrey Paten, Jeffrey William Ruberti

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Description

Conventionally, many procedures have been developed and used for assembly of polymeric fibers such as collagen fibrils; however, none of the existing procedures are customized.  Moreover, the strain directed assembly of collagen fibrils has never been disclosed earlier.  Some of the other limitations associated with existing procedures/techniques are fabrication of unorganized fibrils, non-reproducibility, assembly of small sized fibrils, and reduced efficacy.  This approach discloses a novel procedure for fabrication of collagen fibers from a solution of monomers.

 Technology Overview

This innovation technique requires that collagen monomers or precursor microfibrils accumulate at an interface or in bulk solution. The concentration of the accumulated monomers should be in the range of 1.2 mg/ml to 200 mg/ml. Once the monomers microfibrils have accumulated a drawing probe contacts the solution interface or bulk solution and organized collagen fibers are drawn from the solution. After a fiber or arrays of fibers is drawn, they further exposed to a solution which promotes re-crystallization. 

This solution could be for any collagen fibril forming buffer including osmotic agents such as Polyethylene glycol or Hyaluronic acid. 

Value Proposition

  • Is highly repeatable

  • Effectively allows for a strain directed assembly of collagen fibrils

  • Allows for an assembly of highly organized and aligned collagen fibrils

  • Enables the use of a solution/air interface to generate the required strain

  • Is highly customized, enabling a change of collagen concentration ranges, magnitude/distribution of strain and the re‑hydration environment

  • Allows for a fiber drawing rate of 1 micron/sec to 1 cm/sec

  • Allows for the concentration of accumulated monomers in the preferred range of 2.4-100 mg/ml

  • Enables an adjustment of key process parameters such as temperature, ionic strength, pH and buffers

 

•Would be commercially useful for various applications such as:

o Fabrication of connective tissues

o Organized scaffolding for regenerative medicine

o Tissue repair

o Alignment guide for other molecules such as carbon nanotubes

 

Intellectual Property status

Provisional Application 61/760,396

License status

Available for license

Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Jeffrey Paten
Jeffrey Ruberti
Keywords: