This invention uses a nanopore, which allows diffusion of small molecules and ions across two chambers in a way such that the flux depends on the nominal size of the opening. If an antigen binds to the mouth of a pore that is functionalized to a specific antigen, the resulting flux through the nanopore would be much smaller than the flux of an open pore. Therefore, antigen binding to the pore serves to produce a “transistor-like” response that reduces flux through the pore. The dynamic range of the sensor can be adjusted by modulating the affinity of the receptor to the analyte as well as the size of the array in the nanopore. 
Technology Overview
Northeastern University researchers have proposed an idea for an electronics-free device for in-field visualization of antigen-analyte binding in a portable test-strip. No power is required in this invention, and a rapid visual result will be displayed in 10 min. This device contains: 
i) A chip with multiple arrays of solid-state pores (of sizes 75-100 nm) that are functionalized with receptors that bind antigen with moderate to high affinity
ii) Two fluidic chambers that serve as the top and bottom chambers that the pore arrays are in contact with
iii) Inlet/outlet for sample introduction and flow-through
iv) Ionophore/ion solutions for signal generation
- Senses the antigen directly, and amplification of the signal is achieved using an electronics-free platform (portable)
- Device manufacturing is inexpensive
- Virus detection
- Can be used for in-field visualization of antigen-analyte binding in a portable test-strip 
- License
- Partnering
- Research collaboration
Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
Meni Wanunu