Description:

Background

Bacterial genetic resistance to antibiotics is a major concern as it renders antibiotics ineffective. To combat this, various drug delivery systems have been developed however none of the strategies are effective due to limitations such as multiple dosage requirements, ineffective treatment, and reduced shelf life. There remains a need for a robust novel antibiotic drug delivery system. 

Technology Overview

Researchers have developed a class of silver palladium nanoparticles that not only provide an antimicrobial effect but also act as an imaging agent for bacterial detection. These particles detect where the infection is, treat the infection, and then determine if the infection is being reduced. 

Researchers at Northeastern University have synthesized silver palladium nanoparticles for dual action as bactericidal and imaging. The precursors are mixed at room temperature. The ascorbic acid solution was added for chemical reduction and sonicated. The precipitates were collected by centrifugation and washed with (DI) water to remove the surfactant and excess reactants. The effect of these nanoparticles was tested on bacterial colonies. 

Benefits

New synthesis method for silver palladium nanoparticles 

  • Dual-use of the nanoparticles 
  • Minimal adverse effects 
  • Simple synthesis method 

Applications

 These nanoparticles can be used for anti-infection agents including: 

  • Coatings on implants 
  • Anti-infection creams 
  • Diagnosis tool for determining infection 
  • Functionalizing the palladium with regions to attach to MRSA and other bacteria to determine which bacteria are present after antibiotic treatment. 

Opportunity

  • License 
  • Partnering 
  • Research collaboration 
Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Aida Ruiz
Thomas Webster
Keywords: