Description:

INV-19045

Background

The development of high-quality and bioresorbable biomaterials in the field of regenerative medicine and drug delivery is of high importance. The desirable biomaterial should also maintain cell function in the body, prevent bacterial colonization, and subsequent infections. The alloy composed of Magnesium-Zinc (Mg-Zn) has gained considerable attention in the design of implantable biomaterials due to its mechanical property and biodegradability. However, easy degradation of the Mg-Zn alloy in human body fluid causes the loss of its structural integrity and uniformity. The atomic layer deposition method (ALD) has offered a promising solution for the development of highly uniform and conformal biomaterials with precise thickness. This invention overcomes the current limitations of biomaterials by applying the ALD technique. 

Technology Overview

Researchers at Northeastern developed a coating composed of TiO2 with the ADL technique that maintains uniformity of the implant and enhances its overall outcome. The ADL TiO2 uniform coating with a controllable thickness can be applied to diverse substrates such as Mg-Zn alloy. The combination of Mg-Zn alloy with ADL TiO2 coating can be used for the development of vascular stents, orthopedic and dental implants. The developed combination easily integrates in the human tissue, enhance protein deposition and cell proliferation; simultaneously preventing the formation of bacterial colonization and infection. A broad range of other substrates with various applications can also be coated with ADL TiO2

Benefits

  • Prevents corrosion of MG-Zn alloy in human body fluids 
  • Decreased bacterial proliferation 
  • Less demand for antibiotics 
  • Uniform thickness
  • Improved adhesion between the substrate and coating
  • Clearer FDA pathway likely due to the presence of TiO2

Applications

  • Coating for biomedical implants including those used in coronary artery 
  • Vascular stents 
  • Biomedical sensors
  • Orthopedic implants
  • Dental implants

Opportunity

  • License
  • Partnering
  • Research collaboration
Patent Information:
For Information, Contact:
Mark Saulich
Associate Director of Commercialization
Northeastern University
m.saulich@northeastern.edu
Inventors:
Thomas Webster
Paria Ghannadian
Fan Yang
James Moxley
Keywords:
Antibacterial properties
Atomic layer deposition
Biomedical implants
Enhanced mammalian cell proliferation
Titanium dioxide nano-thin film deposition